Vasovagal Syncope Is Associated with Variants in Genes Involved in Neurohumoral Signaling Pathways.

ABSTRACT: Vasovagal syncope (VVS) is the most common cause of sudden loss of consciousness. VVS results from cerebral hypoperfusion, due to abnormal autonomic control of blood circulation, leading to arterial hypotension. It is a complex disease, and its development is largely associated with genetic susceptibility. Since abnormal neurohumoral regulation plays an important role in VVS development, we analyzed the association of VVS with polymorphic variants of ADRA1A, ADRB1, HTR1A, ADORA2A, COMT, and NOS3 genes, the products of which are involved in neurohumoral signaling, in patients with a confirmed VVS diagnosis (157 subjects) and individuals without a history of syncope (161 subjects). We were able to identify the associations between VVS and alleles/gen

SUBMITTER: Titov B 

PROVIDER: S-EPMC9498630 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature