Responsive Hyaluronic Acid-Ethylacrylamide Microgels Fabricated Using Microfluidics Technique.

ABSTRACT: Volume changes of responsive microgels can probe interactions between polyelectrolytes and species of opposite charges such as peptides and proteins. We have investigated a microfluidics method to synthesize highly responsive, covalently crosslinked, hyaluronic acid microgels for such purposes. Sodium hyaluronate (HA), pre-modified with ethylacrylamide functionalities, was crosslinked in aqueous droplets created with a microfluidic technique. We varied the microgel properties by changing the degree of modification and concentration of HA in the reaction mixture. The degree of modification was determined by ¹H NMR. Light microscopy was used to investigate the responsiveness of the microgels to osmotic stress in aqueous saline solutions by simultaneously monitoring individual micr

SUBMITTER: Wanselius M 

PROVIDER: S-EPMC9498840 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature