Model Comparison of Heritability Enrichment Analysis in Livestock Population.

ABSTRACT: Heritability enrichment analysis is an important means of exploring the genetic architecture of complex traits in human genetics. Heritability enrichment is typically defined as the proportion of an SNP subset explained heritability, divided by the proportion of SNPs. Heritability enrichment enables better study of underlying complex traits, such as functional variant/gene subsets, biological networks and metabolic pathways detected through integrating explosively increased omics data. This would be beneficial for genomic prediction of disease risk in humans and genetic values estimation of important economical traits in livestock and plant species. However, in livestock, factors affecting the heritability enrichment estimation of complex traits have not been examined. Previous studies on

SUBMITTER: Cai X 

PROVIDER: S-EPMC9498849 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature