Cheminformatics-Based Discovery of Potential Chemical Probe Inhibitors of Omicron Spike Protein.

ABSTRACT: During the past two decades, the world has witnessed the emergence of various SARS-CoV-2 variants with distinct mutational profiles influencing the global health, economy, and clinical aspects of the COVID-19 pandemic. These variants or mutants have raised major concerns regarding the protection provided by neutralizing monoclonal antibodies and vaccination, rates of virus transmission, and/or the risk of reinfection. The newly emerged Omicron, a genetically distinct lineage of SARS-CoV-2, continues its spread in the face of rising vaccine-induced immunity while maintaining its replication fitness. Efforts have been made to improve the therapeutic interventions and the FDA has issued Emergency Use Authorization for a few monoclonal antibodies and drug treatments for COVID-19. However, the

SUBMITTER: Khan SA 

PROVIDER: S-EPMC9498999 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature