Golgi Phosphoprotein 3 Regulates the Physical Association of Glycolipid Glycosyltransferases.

ABSTRACT: Glycolipid glycosylation is an intricate process that mainly takes place in the Golgi by the complex interplay between glycosyltransferases. Several features such as the organization, stoichiometry and composition of these complexes may modify their sorting properties, sub-Golgi localization, enzymatic activity and in consequence, the pattern of glycosylation at the plasma membrane. In spite of the advance in our comprehension about physiological and pathological cellular states of glycosylation, the molecular basis underlying the metabolism of glycolipids and the players involved in this process remain not fully understood. In the present work, using biochemical and fluorescence microscopy approaches, we demonstrate the existence of a physical association between two ganglioside glycosylt

SUBMITTER: Ruggiero FM 

PROVIDER: S-EPMC9499508 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature