A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding.

ABSTRACT: The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the brain is smaller than normal at birth, results mainly from there being fewer neurons in the neocortex because of defects in neural progenitor cells (NPCs). Outer radial glia (oRGs), NPCs that are abundant in gyrencephalic species but rare in lissencephalic species, are thought to play key roles in the expansion and folding of the neocortex. However, how oRGs expand, whether they are necessary for neocortical folding, and whether defects in oRGs cause microcephaly remain important questions in the study of brain development, evolution, and disea

SUBMITTER: Wang L 

PROVIDER: S-EPMC9499540 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature