Using phylogenetics to infer HIV-1 transmission direction between known transmission pairs.

ABSTRACT: Inferring the transmission direction between linked individuals living with HIV provides unparalleled power to understand the epidemiology that determines transmission. Phylogenetic ancestral-state reconstruction approaches infer the transmission direction by identifying the individual in whom the most recent common ancestor of the virus populations originated. While these methods vary in accuracy, it is unclear why. To evaluate the performance of phylogenetic ancestral-state reconstruction to determine the transmission direction of HIV-1 infection, we inferred the transmission direction for 112 transmission pairs where transmission direction and detailed additional information were available. We then fit a statistical model to evaluate the extent to which epidemiological, sampling, geneti

SUBMITTER: Villabona-Arenas CJ 

PROVIDER: S-EPMC9499565 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature