Role of Innate and Adaptive Cytokines in the Survival of COVID-19 Patients.

ABSTRACT: SARS-CoV-2 is a new coronavirus characterized by a high infection and transmission capacity. A significant number of patients develop inadequate immune responses that produce massive releases of cytokines that compromise their survival. Soluble factors are clinically and pathologically relevant in COVID-19 survival but remain only partially characterized. The objective of this work was to simultaneously study 62 circulating soluble factors, including innate and adaptive cytokines and their soluble receptors, chemokines and growth and wound-healing/repair factors, in severe COVID-19 patients who survived compared to those with fatal outcomes. Serum samples were obtained from 286 COVID-19 patients and 40 healthy controls. The 62 circulating soluble factors were quantified using a Luminex Mil

SUBMITTER: Monserrat J 

PROVIDER: S-EPMC9499609 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature