Singularity and Commonality in Response to SARS-CoV-2 in Lung and Colon Cell Models.

ABSTRACT: The systemic nature of COVID-19 with multiple extrapulmonary manifestations of disease, largely due to the wide tissue expression of SARS-CoV-2 major entry factors, as well as the patient-specific features of COVID-19 pathobiology, determine important directions for basic and translational research. In the current study, we addressed the questions of singularities and commonalities in cellular responses to SARS-CoV-2 and related SARS-CoV on the basis of compendium-wide analysis of publicly available transcriptomic datasets as part of the herein implemented multi-modular UNCOVIDING approach. We focused on cellular models attributed to the epithelial cells of the respiratory system, the Calu-3 cell line, and epithelial cells of the gastrointestinal tract, the Caco-2 cell line, infected with

SUBMITTER: Meshcheryakova A 

PROVIDER: S-EPMC9499647 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature