Histamine Activates Human Eosinophils via H₂R and H₄R Predominantly in Atopic Dermatitis Patients.

ABSTRACT: Atopic dermatitis (AD) is maintained by a variety of cells and inflammatory mediators, including eosinophils and histamine. We recently reported that eosinophils from AD patients highly express the H₄R. However, its immunomodulatory function in eosinophils is still largely unexplored. In this study, transcriptome analysis of blood eosinophils from AD patients stimulated with histamine and the H₄R agonist ST-1006 revealed several regulated genes (e.g., IL-18R, IL-1RL1, PDE4B, CXCR4) involved in inflammation. Subsequently, the impact of histamine on one of the strongly regulated genes, the IL-18 receptor (IL-18Rα), was investigated in detail. Stimulation with histamine induced the upregulation of IL-18Rα at mRNA and at the protein level in human eosinophils, which was m

SUBMITTER: Beyer L 

PROVIDER: S-EPMC9499661 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature