Identification of Adipose Tissue as a Reservoir of Macrophages after Acute Myocardial Infarction.

ABSTRACT: Medullary and extra-medullary hematopoiesis has been shown to govern inflammatory cell infiltration and subsequently cardiac remodeling and function after acute myocardial infarction (MI). Emerging evidence positions adipose tissue (AT) as an alternative source of immune cell production. We, therefore, hypothesized that AT could act as a reservoir of inflammatory cells that participate in cardiac homeostasis after MI. To reveal the distinct role of inflammatory cells derived from AT or bone marrow (BM), chimeric mice were generated using standard repopulation assays. We showed that AMI increased the number of AT-derived macrophages in the cardiac tissue. These macrophages exhibit pro-inflammatory characteristics and their specific depletion improved cardiac function as well as decreased in

SUBMITTER: Gomez I 

PROVIDER: S-EPMC9499676 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature