Novel Curcumin-Encapsulated α-Tocopherol Nanoemulsion System and Its Potential Application for Wound Healing in Diabetic Animals.

ABSTRACT:

Objective

This project was aimed at formulating a novel nanoemulsion system and evaluating it for open incision wound healing in diabetic animals.

Methods

The nanoemulsions were characterized for droplet size and surface charge, drug content, antioxidant and antimicrobial profiling, and wound healing potential in diabetic animals. The skin samples excised were also analyzed for histology, mechanical strength, and vibrational and thermal analysis.

Results

The optimized nanoemulsion (CR-NE-II) exhibited droplet size of26.76 ± 0.9 nm with negative surface charge (-10.86 ± 1.06 mV), was homogenously dispersed with drug content of68.05 ± 1.2%, released almost82.95 ± 2.2%of the drug within first 2 h of experiment with synergistic antioxidant (95 ± 2.1%) and synergistic anti

SUBMITTER: Ali M 

PROVIDER: S-EPMC9499807 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature