Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases.

ABSTRACT: Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides difficile infection and is considered a promising treatment for other microbiome-related disorders, but a comprehensive understanding of microbial engraftment dynamics is lacking, which prevents informed applications of this therapeutic approach. Here, we performed an integrated shotgun metagenomic systematic meta-analysis of new and publicly available stool microbiomes collected from 226 triads of donors, pre-FMT recipients and post-FMT recipients across eight different disease types. By leveraging improved metagenomic strain-profiling to infer strain sharing, we found that recipients with higher donor strain engraftment were more likely to experience clinical success after FMT (P = 0.017) when eva

SUBMITTER: Ianiro G 

PROVIDER: S-EPMC9499858 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature