Management of Chronic Myeloid Leukemia in Children and Young Adults.

ABSTRACT:

Purpose of review

Due to lack of pediatric-specific data, the management of chronic myeloid leukemia (CML) in pediatric, adolescents, and young adults is guided by adult CML evidence-based recommendations. Pediatric CML presents differently than adult CML and is often a more aggressive disease with different biological and host factors, yet there is sparse literature on how to address those differences.

Recent findings

Over the past two decades, tyrosine kinase inhibitors (TKIs) have changed the way CML is treated. There are currently three FDA-approved TKIs (imatinib, dasatinib, and nilotinib) for pediatric patients. When choosing which TKI to begin treatment with, there are many factors that should be considered on a case-to-case basis to obtain optimal outcomes. The safet

SUBMITTER: Ford M 

PROVIDER: S-EPMC9499901 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature