Differentiating central nervous system infection from disease infiltration in hematological malignancy.

ABSTRACT: Hematological malignancies place individuals at risk of CNS involvement from their hematological disease and opportunistic intracranial infection secondary to disease-/treatment-associated immunosuppression. Differentiating CNS infection from hematological disease infiltration in these patients is valuable but often challenging. We sought to determine if statistical models might aid discrimination between these processes. Neuroradiology, clinical and laboratory data for patients with hematological malignancy at our institution between 2007 and 2017 were retrieved. MRI were deep-phenotyped across anatomical distribution, presence of pathological enhancement, diffusion restriction and hemorrhage and statistically modelled with Bayesian-directed probability networks and multivariate logistic

SUBMITTER: Lim EA 

PROVIDER: S-EPMC9499957 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature