Ontology highlight
ABSTRACT:
SUBMITTER: Upadhya SR
PROVIDER: S-EPMC9499981 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Upadhya Swathi Ramachandra SR Ryan Colm J CJ
Cell reports methods 20220908 9
Large-scale studies of human proteomes have revealed only a moderate correlation between mRNA and protein abundances. It is unclear to what extent this moderate correlation reflects post-transcriptional regulation and to what extent it reflects measurement error. Here, by analyzing replicate profiles of tumors and cell lines, we show that there is considerable variation in the reproducibility of measurements of transcripts and proteins from individual genes. Proteins with more reproducible measu ...[more]