A global epidemiological analysis of COVID-19 vaccine types and clinical outcomes.

ABSTRACT:

Objectives

To compare messenger RNA (mRNA)-based and adenovirus-vectored vaccines (ADVVs) with inactivated virus vaccines (IVVs) using real-world aggregate data.

Methods

We performed longitudinal analyses of publicly accessible epidemiological, clinical, virological, vaccine-related, and other public health data from 41 eligible countries during the first half of 2021. The relationships between vaccination coverage and clinical outcomes were analyzed using repeated measures correlation analyses and mixed-effects modeling to adjust for potential mediating and confounding factors.

Results

Countries that used mRNA and/or ADVV (n = 31) vs IVV, among other vaccine types (n = 10), had different distributions of age (42.4 vs 33.9 years, respectively; P-value = 0.0006), gross

SUBMITTER: Alhinai Z 

PROVIDER: S-EPMC9499984 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature