Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications.

ABSTRACT:

Background & aims

We investigate interrelationships between gut microbes, metabolites, and cytokines that characterize COVID-19 and its complications, and we validate the results with follow-up, the Japanese 4D (Disease, Drug, Diet, Daily Life) microbiome cohort, and non-Japanese data sets.

Methods

We performed shotgun metagenomic sequencing and metabolomics on stools and cytokine measurements on plasma from 112 hospitalized patients with SARS-CoV-2 infection and 112 non-COVID-19 control individuals matched by important confounders.

Results

Multiple correlations were found between COVID-19-related microbes (eg, oral microbes and short-chain fatty acid producers) and gut metabolites (eg, branched-chain and aromatic amino acids, short-chain fatty acids, carbohydrates, n

SUBMITTER: Nagata N 

PROVIDER: S-EPMC9499989 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature