Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology.

ABSTRACT: In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications in tether-free groups of animals have been limited in part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities for optogenetics, pharmacology and photopharmacology. This system features mechanically compliant microfluidic and electronic interconnects, capabilities for dynamic control over the rates of drug delivery and real-time programmability, simultaneously for up to 256 separate devices in a single cage environment. Our behavioral experiments demonstrate control of motor behaviors in grouped mice through in vivo optogenetics wi

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9500026 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature