Development of a new toolbox for mouse PET-CT brain image analysis fully based on CT images and validation in a PD mouse model.

ABSTRACT: Automatic analysis toolboxes are popular in brain image analysis, both in clinical and in preclinical practices. In this regard, we proposed a new toolbox for mouse PET-CT brain image analysis including a new Statistical Parametric Mapping-based template and a pipeline for image registration of PET-CT images based on CT images. The new templates is compatible with the common coordinate framework (CCFv3) of the Allen Reference Atlas (ARA) while the CT based registration step allows to facilitate the analysis of mouse PET-CT brain images. From the ARA template, we identified 27 volumes of interest that are relevant for in vivo imaging studies and provided binary atlas to describe them. We acquired 20 C57BL/6 mice with [¹⁸F]FDG PET-CT, and 12 of them underwent 3D T2-weighted high-r

SUBMITTER: Presotto L 

PROVIDER: S-EPMC9500043 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature