Ca_v2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization.

ABSTRACT: Distant metastasis is the main cause of mortality in breast cancer patients. Using the breast cancer genomic data from The Cancer Genome Atlas (TCGA), we identified brain specific Ca_v2.2 as a critical regulator of metastasis. Ca_v2.2 expression is significantly upregulated in breast cancer and its higher expression is inversely correlated with survival suggesting a previously unappreciated role of Ca_v2.2 in breast cancer. Ca_v2.2 is required for breast cancer migration, invasion, and metastasis. Interestingly, Ca_v2.2 promotes invadopodia formation and extracellular matrix (ECM) degradation through the stabilization of invadopodia component cortactin in a proteosome-dependent manner. Moreover, deubiquitinating enzyme USP43 mediated the fu

SUBMITTER: Xue Y 

PROVIDER: S-EPMC9500045 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature