Craniofacial, dental, and molecular features of Pyle disease in a South African child.

ABSTRACT:

Introduction

Pyle Disease (PD), or familial metaphyseal dysplasia [OMIM 265900], is a rare autosomal recessive condition leading to widened metaphyses of long bones and cortical bone thinning and genu valgum. We detail the oro-dental and molecular findings in a South African patient with PD.

Methods

The patient underwent clinical, radiographic and molecular examinations. An exfoliated tooth was analysed using scanning electron microscopy and was compared to a control tooth.

Results

The patient presented with marked Erlenmeyer-flask deformity (EFD) of the long bones and several Wormian bones. His dental development was delayed by approximately three years. The permanent molars were mesotaurodontic. The bones, including the jaws and cervical vertebrae, showed osteoporot

SUBMITTER: Chetty M 

PROVIDER: S-EPMC9500065 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature