Association of Time in Range with Endothelial Injury in Patients with Type 2 Diabetes Treated with Exenatide.

ABSTRACT:

Introduction

We aimed to investigate whether treatment with exenatide could increase time in range (TIR) and decrease glycemic variability, and to evaluate the association between TIR and endothelial injury in patients with type 2 diabetes mellitus (T2DM).

Methods

Two-hundred patients with T2DM treated with exenatide for 16 weeks were included in this study. Seven-point fingerstick blood glucose was used to evaluate derived TIR and glycemic variability. The serum levels of soluble endothelial cell protein C receptor (sEPCR) and von Willebrand factor (vWF) were measured. Ninety-three patients having the data of endothelial injury markers were categorized as derived TIR > 70% or ≤ 70% after the treatment and the association between TIR and endothelial injury were evaluated.

SUBMITTER: Le Y 

PROVIDER: S-EPMC9500125 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature