The plasticity of cardiac sympathetic nerves and its clinical implication in cardiovascular disease.

ABSTRACT: The heart is electrically and mechanically controlled by the autonomic nervous system, which consists of both the sympathetic and parasympathetic systems. It has been considered that the sympathetic and parasympathetic nerves regulate the cardiomyocytes' performance independently; however, recent molecular biology approaches have provided a new concept to our understanding of the mechanisms controlling the diseased heart through the plasticity of the autonomic nervous system. Studies have found that cardiac sympathetic nerve fibers in hypertrophic ventricles strongly express an immature neuron marker and simultaneously cause deterioration of neuronal cellular function. This phenomenon was explained by the rejuvenation of cardiac sympathetic nerves. Moreover, heart failure and myocardial in

SUBMITTER: Kanazawa H 

PROVIDER: S-EPMC9500163 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature