Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis.

ABSTRACT:

Objective

Osteosarcoma (OS) is an aggressive, highly metastatic, relatively drug-resistant bone tumor with poor long-term survival rates. The presence and persistence of circulating tumor cells (CTCs) in the peripheral blood are believed to be associated with treatment inefficiency and distant metastases. A blood-based CTC test is thus greatly needed for monitoring disease progression and predicting clinical outcomes. However, traditional methods cannot detect CTCs from tumors of mesenchymal origin such as OS, and research on CTC detection in mesenchymal tumors has been hindered for years.

Methods

In this study, we developed a CTC test based on hexokinase 2, a metabolic function-associated marker, for the detection and surveillance of OS CTCs, and subsequently explored its c

SUBMITTER: Mu H 

PROVIDER: S-EPMC9500224 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature