Characterization of lipomatous tumors with high-resolution ¹H MRS at 17.6T: Do benign lipomas, atypical lipomatous tumors and liposarcomas have a distinct metabolic signature?

ABSTRACT:

Background

Distinguishing between some benign lipomas (BLs), atypical lipomatous tumors (ALTs), and dedifferentiated liposarcomas (DDLs) can be challenging due to overlapping magnetic resonance imaging characteristics, and poorly understood molecular mechanisms underlying the malignant transformation of liposarcomas.

Purpose

To identify metabolic biomarkers of the lipomatous tumor spectrum by examining human tissue specimens using high-resolution ¹H magnetic resonance spectroscopy (MRS).

Materials and methods

In this prospective study, human tissue specimens were obtained from participants who underwent surgical resection for radiologically-indeterminate lipomatous tumors between November 2016 and May 2019. Tissue specimens were obtained from normal subcuta

SUBMITTER: Bharti SK 

PROVIDER: S-EPMC9500232 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature