White matter alterations in pediatric brainstem glioma: An national brain tumor registry of China study.

ABSTRACT:

Background

Previous studies have identified alterations in structural connectivity of patients with glioma. However, white matter (WM) integrity measured by diffusion kurtosis imaging (DKI) in pediatric patients with brainstem glioma (BSG) was lack of study. Here, the alterations in WM of patients with BSG were assessed through DKI analyses.

Materials and methods

This study involved 100 patients with BSG from the National Brain Tumor Registry of China (NBTRC) and 50 age- and sex-matched healthy controls from social recruitment. WM tracts were segmented and reconstructed using U-Net and probabilistic bundle-specific tracking. Next, automatic fiber quantitative (AFQ) analyses of WM tracts were performed using tractometry module embedded in TractSeg.

Results

WM quantitat

SUBMITTER: Zhang P 

PROVIDER: S-EPMC9500240 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature