Mailuoshutong pill for varicocele-associated male infertility-Phytochemical characterisation and multitarget mechanism.

ABSTRACT: Background: Varicocele (VC) is a relatively common and treatable cause of male infertility. Mailuoshutong pill (MLST), a traditional Chinese patent medicine, is widely used for treating varicose vein disease, but the underlying mechanism of MLST on varicocele-associated male infertility is unclear. Objective: To reveal the phytochemical characterisation and multitarget mechanism of MLST on varicocele-associated male infertility. Methods: The components in MLST were determined using UHPLC-MS/MS. Through network analysis, we constructed the "Drug-Components-Targets-Disease" network and predicted the potential biological functions and signaling pathways of MLST. Finally, the therapeutic effects and potential mechanisms of MLST were discovered by pharmacological experiment

SUBMITTER: Lv D 

PROVIDER: S-EPMC9500298 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature