No evidence for widespread positive selection on double substitutions within codons in primates and yeasts.

ABSTRACT: Nucleotide substitutions in protein-coding genes can be divided into synonymous (S) and non-synonymous (N) ones that alter amino acids (including nonsense mutations causing stop codons). The S substitutions are expected to have little effect on function. The N substitutions almost always are affected by strong purifying selection that eliminates them from evolving populations. However, additional mutations of nearby bases can modulate the deleterious effect of single N substitutions and, thus, could be subjected to the positive selection. This effect has been demonstrated for mutations in the serine codons, stop codons and double N substitutions in prokaryotes. In all abovementioned cases, a novel technique was applied that allows elucidating the effects of selection on double substitution

SUBMITTER: Belinky F 

PROVIDER: S-EPMC9500374 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature