Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia.

ABSTRACT: The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments of potential deep brain recording targets performed a rhythmic figure-8 drawing task. Two subjects had dystonia, one was undergoing testing for treatment of Tourette Syndrome and had neither dystonia nor abnormal movements during testing. Movement-related signals were evaluated by determining the magnitude of task-related frequency components. Brain signals were recorded in globus pallidus internus (GPi), the ventral oralis anterior/posterior (VoaVop) and the ventral intermediate (Vim) nuclei of the thalamus. In comparison to the subject without dystonia, both children with dystonia showed increased task-rel

SUBMITTER: Hernandez-Martin E 

PROVIDER: S-EPMC9500435 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature