Varenicline and Lorcaserin for Smoking Cessation and Weight Gain Prevention: A Randomized Clinical Trial.

ABSTRACT:

Objective

To evaluate the safety and effectiveness of combination varenicline with lorcaserin in preventing post-cessation weight gain.

Participants and methods

We conducted a randomized (varenicline for 12 weeks + lorcaserin for 24 weeks vs varenicline for 12 weeks + placebo for 24 weeks) phase II clinical study to obtain preliminary data on the safety and effectiveness of combination varenicline and lorcaserin in preventing post-cessation weight gain in overweight and obese smokers. Eighty-four overweight and obese (body mass index [BMI], 27-40 kg/m²) cigarette smokers were randomized before study termination (lorcaserin: n=40; placebo: n=44). The primary outcomes were weight and waist circumference (WC) changes at 12 and 24 weeks in smokers meeting criteria for

SUBMITTER: Hurt RT 

PROVIDER: S-EPMC9500518 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature