Scattered Tubular Cells Markers in Macula Densa of Normal Human Adult Kidney.

ABSTRACT:

Background

The scattered tubular cells (STCs) are a population of resident progenitor tubular cells with expansion, self-renewal and epithelial differentiation abilities. Although these cells are localized within the proximal (PTs) and distal (DTs) tubules in a normal adult kidney, their presence has never been demonstrated in human macula densa (MD). The purpose of the present study is to describe the presence of STCs in MD using specific markers such as prominin-1 (CD133), cytokeratin 7 (KRT7) and vimentin (VIM).

Methods

We analyzed two sets of three consecutive serial sections for each sample. The first sections of each set were immunostained for nNOS to identify MD, the second sections were immune-stained for CD133 (specific STCs marker) while the third sections were ana

SUBMITTER: Tossetta G 

PROVIDER: S-EPMC9500602 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature