Multifarious Translational Regulation during Replicative Aging in Yeast.

ABSTRACT: Protein synthesis is strictly regulated during replicative aging in yeast, but global translational regulation during replicative aging is poorly characterized. To conduct ribosome profiling during replicative aging, we collected a large number of dividing aged cells using a miniature chemostat aging device. Translational efficiency, defined as the number of ribosome footprints normalized to transcript abundance, was compared between young and aged cells for each gene. We identified more than 700 genes with changes greater than twofold during replicative aging. Increased translational efficiency was observed in genes involved in DNA repair and chromosome organization. Decreased translational efficiency was observed in genes encoding ribosome components, transposon Ty1 and Ty2 genes, transc

SUBMITTER: Zhao T 

PROVIDER: S-EPMC9500732 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature