Comparative Study of Chemical Stability of a PK20 Opioid-Neurotensin Hybrid Peptide and Its Analogue [Ile⁹]PK20-The Effect of Isomerism of a Single Amino Acid.

ABSTRACT: Chemical stability is one of the main problems during the discovery and development of potent drugs. When ignored, it may lead to unreliable biological and pharmacokinetics data, especially regarding the degradation of products' possible toxicity. Recently, two biologically active drug candidates were presented that combine both opioid and neurotensin pharmacophores in one entity, thus generating a hybrid compound. Importantly, these chimeras are structurally similar except for an amino acid change at position 9 of the peptide chain. In fact, isoleucine (C₆H₁₃NO₂) was replaced with its isomer tert-leucine. These may further lead to various differences in hybrids' behavior under specific conditions (temperature, UV, oxidative, acid/base environment).

SUBMITTER: Zyzynska-Granica B 

PROVIDER: S-EPMC9500858 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature