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Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea.

ABSTRACT: Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-β-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3-7). The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data and application of the CD technique. The potential biological activities of secoatractylohexone A were predicted by network pharmacology in silico, the result of which indicated that secoatractylohexone A may be used to treat type II diabetes.

SUBMITTER: Liu L

PROVIDER: S-EPMC9500871 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea.

Liu Lanying L Guan Fuqin F Chen Yu Y Wang Fan F Chen Pengxu P Yin Min M Wang Bi B Li Linwei L Wang Qizhi Q Gu Yonghua Y Feng Xu X

Molecules (Basel, Switzerland) 20220906 18

Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-β-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3-7). The structures of 1 and 2 were elucidated on the basis of ...[more]

PMID: 36144486

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Mild shading promotes sesquiterpenoid synthesis and accumulation in Atractylodes lancea by regulating photosynthesis and phytohormones.

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Endophytic Bacterium-Triggered Reactive Oxygen Species Directly Increase Oxygenous Sesquiterpenoid Content and Diversity in Atractylodes lancea.

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