Association of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population.

ABSTRACT: Argonaute (AGO) proteins, through their key role in the regulation of gene expression, participate in many biological processes, including cell differentiation, proliferation, death and DNA repair. Accurate regulation of gene expression appears to be important for the proper development of complex neural circuits. Loss of AGO proteins is known to lead to early embryonic mortality in mice with various malformations, including anomalies of the central nervous system. Single-nucleotide polymorphisms (SNPs) of AGO genes can lead to deregulation of the processes in which AGO proteins are involved. The contribution of different SNPs in depression has been extensively studied. However, there are hardly any studies on the contribution of AGO genes. The aim of our research was to assess the relatio

SUBMITTER: Kowalczyk M 

PROVIDER: S-EPMC9500920 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature