Genetic Causal Association between Iron Status and Osteoarthritis: A Two-Sample Mendelian Randomization.

ABSTRACT: Objective: Observational studies have shown the association between iron status and osteoarthritis (OA). However, due to difficulties of determining sequential temporality, their causal association is still elusive. Based on the summary data of genome-wide association studies (GWASs) of a large-scale population, this study explored the genetic causal association between iron status and OA. Methods: First, we took a series of quality control steps to select eligible instrumental SNPs which were strongly associated with exposure. The genetic causal association between iron status and OA was analyzed using the two-sample Mendelian randomization (MR). Inverse-variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods were used for analysis. The results were main

SUBMITTER: Xu J 

PROVIDER: S-EPMC9501024 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature