West Mexico Berries Modulate α-Amylase, α-Glucosidase and Pancreatic Lipase Using In Vitro and In Silico Approaches.

ABSTRACT: The objective was to evaluate the antioxidant and biological potential of eight freeze-dried berry varieties of southern Jalisco using in silico and in vitro approaches. Fourteen tentative phenolic compounds were identified in berries by ESI-QToF, including anthocyanins, phenolic acids, flavanols and flavonols. In silico assays of phytochemicals in the berry inhibiting enzymes related to obesity and diabetes showed predicted binding energy interactions (ranging from -5.4 to -9.3 kcal/mol). Among the cultivars, antioxidant potential for DPPH IC₅₀ ranged from 1.27 to 3.40 mg/mL, ABTS IC₅₀ from 2.26 to 7.32 mg/mL and nitric oxide (NO) inhibition IC₅₀ from 4.26 to 11.07 mg/mL. The potential to inhibit α-amylase IC₅₀ ranged from 4.02 to 7.66 mg/mL, α-

SUBMITTER: Virgen-Carrillo CA 

PROVIDER: S-EPMC9501167 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature