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CLAIRE-Parallelized Diffeomorphic Image Registration for Large-Scale Biomedical Imaging Applications.


ABSTRACT: We study the performance of CLAIRE-a diffeomorphic multi-node, multi-GPU image-registration algorithm and software-in large-scale biomedical imaging applications with billions of voxels. At such resolutions, most existing software packages for diffeomorphic image registration are prohibitively expensive. As a result, practitioners first significantly downsample the original images and then register them using existing tools. Our main contribution is an extensive analysis of the impact of downsampling on registration performance. We study this impact by comparing full-resolution registrations obtained with CLAIRE to lower resolution registrations for synthetic and real-world imaging datasets. Our results suggest that registration at full resolution can yield a superior registration quality-but not always. For example, downsampling a synthetic image from 10243 to 2563 decreases the Dice coefficient from 92% to 79%. However, the differences are less pronounced for noisy or low contrast high resolution images. CLAIRE allows us not only to register images of clinically relevant size in a few seconds but also to register images at unprecedented resolution in reasonable time. The highest resolution considered are CLARITY images of size 2816×3016×1162. To the best of our knowledge, this is the first study on image registration quality at such resolutions.

SUBMITTER: Himthani N 

PROVIDER: S-EPMC9501197 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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CLAIRE-Parallelized Diffeomorphic Image Registration for Large-Scale Biomedical Imaging Applications.

Himthani Naveen N   Brunn Malte M   Kim Jae-Youn JY   Schulte Miriam M   Mang Andreas A   Biros George G  

Journal of imaging 20220916 9


We study the performance of CLAIRE-a diffeomorphic multi-node, multi-GPU image-registration algorithm and software-in large-scale biomedical imaging applications with billions of voxels. At such resolutions, most existing software packages for diffeomorphic image registration are prohibitively expensive. As a result, practitioners first significantly downsample the original images and then register them using existing tools. Our main contribution is an extensive analysis of the impact of downsam  ...[more]

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