Tumor-Suppressive and Oncogenic Roles of microRNA-149-5p in Human Cancers.

ABSTRACT: Malignant tumors are always a critical threat to human health, with complex pathogenesis, numerous causative factors, and poor prognosis. The features of cancers, such as gene mutations, epigenetic alterations, and the activation and inhibition of signaling pathways in the organism, play important roles in tumorigenesis and prognosis. MicroRNA (miRNA) enables the control of various molecular mechanisms and plays a variety of roles in human cancers, such as radiation sensitivity and tumor immunity, through the regulation of target genes. MiR-149-5p participates in the process and is closely related to lipogenesis, the migration of vascular endothelial cells, and the expression of stem-cell-related proteins. In recent years, its role in cancer has dramatically increased. In this review, we s

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9501226 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature