In Vivo Skin Regeneration and Wound Healing Using Cell Micro-Transplantation.

ABSTRACT: Background: The accumulation of senescent cells in tissues alters tissue homeostasis and affects wound healing. It is also considered to be the main contributing factor to aging. In addition to losing their ability to divide, senescent cells exert detrimental effects on surrounding tissues through their senescence-associated secretory phenotype (SASP). They also affect stem cells and their niche, reducing their capacity to divide which increasingly reduces tissue regenerative capacity over time. The aim of our study was to restore aged skin by increasing the fraction of young cells in vivo using a young cell micro-transplantation technique on Fischer 344 rats. Employing the same technique, we also used wild-type skin fibroblasts and stem cells in order to heal Dominant Dystrophic Ep

SUBMITTER: Nanic L 

PROVIDER: S-EPMC9501230 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature