Gene Networks and Pathways Involved in Escherichia coli Response to Multiple Stressors.

ABSTRACT: Stress response helps microorganisms survive extreme environmental conditions and host immunity, making them more virulent or drug resistant. Although both reductionist approaches investigating specific genes and systems approaches analyzing individual stress conditions are being used, less is known about gene networks involved in multiple stress responses. Here, using a systems biology approach, we mined hundreds of transcriptomic data sets for key genes and pathways involved in the tolerance of the model microorganism Escherichia coli to multiple stressors. Specifically, we investigated the E. coli K-12 MG1655 transcriptome under five stresses: heat, cold, oxidative stress, nitrosative stress, and antibiotic treatment. Overlaps of transcriptional changes between studies of

SUBMITTER: Abdelwahed EK 

PROVIDER: S-EPMC9501238 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature