Molecular Approaches and Echocardiographic Deformation Imaging in Detecting Myocardial Fibrosis.

ABSTRACT: The pathological remodeling of myocardial tissue is the main cause of heart diseases. Several processes are involved in the onset of heart failure, and the comprehension of the mechanisms underlying the pathological phenotype deserves special attention to find novel procedures to identify the site of injury and develop novel strategies, as well as molecular druggable pathways, to counteract the high degree of morbidity associated with it. Myocardial fibrosis (MF) is recognized as a critical trigger for disruption of heart functionality due to the excessive accumulation of extracellular matrix proteins, in response to an injury. Its diagnosis remains focalized on invasive techniques, such as endomyocardial biopsy (EMB), or may be noninvasively detected by cardiac magnetic resonance imaging

SUBMITTER: Sonaglioni A 

PROVIDER: S-EPMC9501415 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature