Cutting-Edge Delivery Systems and Adjuvants in Tolerogenic Vaccines: A Review.

ABSTRACT: Conventional therapies for immune-mediated diseases, including autoimmune disorders, transplant reactions, and allergies, have undergone a radical evolution in the last few decades; however, they are still not specific enough to avoid widespread immunosuppression. The idea that vaccine usage could be extended beyond its traditional immunogenic function by encompassing the ability of vaccines to induce antigen-specific tolerance may revolutionize preventive and therapeutic strategies in several clinical fields that deal with immune-mediated disorders. This approach has been supported by improved data relating to the several mechanisms involved in controlling unwanted immune responses and allowing peripheral tolerance. Given these premises, several approaches have been developed to induce pe

SUBMITTER: Puricelli C 

PROVIDER: S-EPMC9501480 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature