Enantioselective Cyclopropanation Catalyzed by Gold(I)-Carbene Complexes.

ABSTRACT: The formation of polysubstituted cyclopropane derivatives in the gold(I)-catalyzed reaction of olefins and propargylic esters is a potentially useful transformation to generate diversity, therefore any method in which its stereoselectivity could be controlled is of significant interest. We prepared and tested a series of chiral gold(I)-carbene complexes as a catalyst in this transformation. With a systematic optimization of the reaction conditions, we were able to achieve high enantioselectivity in the test reaction while the cis:trans selectivity of the transformation was independent of the catalyst. Using the optimized conditions, we reacted a series of various olefins and acetylene derivatives to find that, although the reactions proceeded smoothly and the products were usually i

SUBMITTER: Szabo Z 

PROVIDER: S-EPMC9501563 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature