Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background.

ABSTRACT: A wide range of viruses cause neurological manifestations in their hosts. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the brain, depending in part on host genetic background. The interaction between host genetic background, neurological response to viral infection, and subsequent clinical manifestations remains poorly understood. In the present study, we used the genetically diverse Collaborative Cross (CC) mouse resource to better understand how differences in genetic background drive clinical signs and neuropathological manifestations of acute Theiler's murine encephalomyelitis virus (TMEV) infection. For the first time, we characterized variations of TMEV viral tropism and load b

SUBMITTER: Lawley KS 

PROVIDER: S-EPMC9501595 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature