Epineural Methylene Blue Injection May Aid Localization of Digital Nerves in Dupuytren's Surgery.

ABSTRACT:

Background

In Dupuytren's surgery, limited fasciectomy is still the gold-standard treatment. A relatively high risk of iatrogenic nerve injury has been observed especially when the spiral cords of the Dupuytren's tissue pull digital nerves away from their normal anatomical location. Intraoperative neural marking could facilitate locating the potentially displaced nerves. Hence, surgery could be undertaken more quickly with a lower risk of iatrogenic nerve injury.

Objectives

We hypothesize that digital nerves may be stained with methylene blue (MB) in vivo providing a visual aid to distinguish them from Dupuytren's tissue. We aim to (a) test an in vivo nerve staining technique using MB in a rat sciatic nerve model and to (b) assess the safety of epineural MB injection.

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SUBMITTER: Szabo T 

PROVIDER: S-EPMC9501739 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature