Cyclopropane-Fused N-Heterocycles via Aza-Heck-Triggered C(sp³)-H Functionalization Cascades.

ABSTRACT: Unique examples of aza-Heck-based C(sp³)-H functionalization cascades are described. Under Pd(0)-catalyzed conditions, the aza-Heck-type cyclization of N-(pentafluorobenzoyloxy)carbamates generates alkyl-Pd(II) intermediates that effect C(sp³)-H palladation en route to cyclopropanes. Key factors that control the site selectivity of the cyclopropanation process have been elucidated such that selective access to a wide range of ring- or spiro-fused systems can be achieved.

SUBMITTER: Jing C 

PROVIDER: S-EPMC9501755 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature