Heterogeneity of Frailty Trajectories and Associated Factors in the Lothian Birth Cohort 1936.

ABSTRACT:

Introduction

Recent research suggests that the experience of frailty progression may be heterogeneous, with latent subpopulations of older adults following distinct trajectories of frailty. We aimed to investigate this notion and determine whether certain factors are associated with the membership of these subpopulations.

Methods

Data from 5 data waves collected over 12 years in participants of the Lothian Birth Cohort 1936, aged 70 at baseline, were used to derive the frailty index (FI) (NW1 = 1,091, NW5 = 431). These were used in latent class mixed modelling to estimate subpopulations of frailty trajectories.

Results

A quadratic latent class mixed model found 3 distinct groupings, which followed a low (61%, n = 632), medium (36%, n = 368), or high (3%, n = 28) FI tr

SUBMITTER: Welstead M 

PROVIDER: S-EPMC9501780 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature