Reversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior.

ABSTRACT: Cells adhering onto surfaces sense and respond to chemical and physical surface features. The control over cell adhesion behavior influences cell migration, proliferation, and differentiation, which are important considerations in biomaterial design for cell culture, tissue engineering, and regenerative medicine. Here, we report on a supramolecular-based approach to prepare reversible self-assembled monolayers (rSAMs) with tunable lateral mobility and dynamic control over surface composition to regulate cell adhesion behavior. These layers were prepared by incubating oxoacid-terminated thiol SAMs on gold in a pH 8 HEPES buffer solution containing different mole fractions of ω-(ethylene glycol)_2-4- and ω-(GRGDS)-, α-benzamidino bolaamphiphiles. Cell shape and morphology were infl

SUBMITTER: Yeung SY 

PROVIDER: S-EPMC9501787 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature